Retrovirus maturation—an extraordinary structural transformation

Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA.

Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary carcinoma, a unique animal model for human bronchioalveolar carcinoma. We previously isolated a JSRV proviral clone and showed that it was both infectious and oncogenic. Thus JSRV is necessary and sufficient for the development of ovine pulmonary carcinoma, but no data are available on the mechanisms of transformation....

India’s Atypical Structural Transformation

transformation. Structural transformation is the reallocation of economic activity across the broad sectors of agriculture, manufacturing, and services that accompanies the process of modern economic growth. Long-term evidence from developed countries indicates two stages of structural transformation: labor moves (i) out of agriculture into manufacturing and services and then (ii) out of both a...

China’s Structural Transformation

Extraordinary claims require extraordinary evidence.

At the beginning of 2003, the Journal of Health Economics published a paper of great importance in public policy by DiMasi, Hansen, and Grabowski (referred to hereafter as “DHG 2003”). The paper is based primarily on confidential, proprietary data supplied by pharmaceutical companies to the Tufts Center for the Study of Drug Development, a research center that receives significant unrestricted ...

Extraordinary claims require extraordinary evidence

We thank Light and Warburton (2005) [hereafter LW] for providing a context for us to further discuss and clarify our studies on the cost of new drug development (DiMasi et al., 2003 [hereafter DHG]; DiMasi et al., 1991b [hereafter DHGL]; Hansen, 1979). We disagree, however, with their analyses, comparators, and conclusions. Although LW suggest, through the invocation of selected reported cost f...